Patent Ductus Arteriosus: Advances and Controversies

Manoj Varanattu Chellappan

Significant patent ductus arteriosus (PDA) is detected in nearly one-third of very-low-birth-weight neonates admitted to neonatal intensive care units. Management of PDA in preterm neonates has been a conundrum ever since Powell, in 1963, reported the surgical closure of PDA in a preterm infant with respiratory distress syndrome. Even after continued research, the indications and the optimal timing of closure of PDA in preterm infants still remain unclear. There is an uncertainty regarding the treatments that have a positive effect on both short-term and long-term outcomes.

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