Comparison of Serum VEGF and PlGF Levels in Preeclamptic and Healthy Pregnant Women in Hamadan, Iran

Shahla Nasrolahi, Younes Mohammadi, Roghaye Abbasalipourkabir, Sedigheh Kamkari

Abstract

Background and Aims: Serum vascular endothelial growth factor (VEGF) and placental growth factor (PlGF) levels are found to be decreased in women both at the time of diagnosis of preeclampsia and well in advance of syndrome onset.

The aims of this study were to compare the levels of VEGF and PlGF in preeclamptic and healthy pregnant women and evaluate the association between their levels in preeclampsia and the risk of severity of preeclampsia.

Materials and Methods: Blood samples were collected from preeclamptic and healthy pregnant women in 20+0 to 40+6 weeks of gestational age. Serum VEGF and PlGF levels were determined and analyzed. Preeclamptic women were closely monitored—some of them developed severe preeclampsia and their pregnancies were terminated due to fetal and maternal complications.

Results: There was a significant difference in the mean serum levels of VEGF and PlGF in the 2 groups (P < .05). Serum VEGF and PlGF levels were lower among preeclamptic women compared with healthy pregnant women and still lower in women who developed severe preeclampsia (P < .001).

Conclusion: VEGF and PlGF levels can predict the risk of preeclampsia during pregnancy. Further, extensive researches on VEGF and PlGF levels and other angiogenic substances (such as sFLT-1, PP-13, and sEng), with large sample sizes are needed.

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