Congenital Haemophilus influenzae Sepsis With Acute Renal Failure in a Term Neonate

Karampatsas Kostas, Raghavan Shankar Prasad, Jeewan Rawal, George Vasileiadis


An 18-year-old primigravida, immunized for Haemophilus influenzae type b, had prolonged rupture of membranes (PROM) and signs of perinatal infection. She delivered a term neonate at 39+2 weeks of gestation. The neonate weighted 3800 g at birth and was in a poor state of health, requiring resuscitation and admission to the neonatal intensive care unit. The neonate was diagnosed with nontypeable H influenzae (NTHi) sepsis with acute renal failure. After treatment with broad-spectrum antibiotics and fluid and electrolyte management, the neonate recovered and was discharged on day 10.

Early-onset neonatal NTHi sepsis is associated with prematurity and is a rare disease in term neonates. Furthermore, acute renal failure is a rare but severe complication. This case report underlines the importance of perinatal and neonatal management in the presence of maternal illness and/or PROM and also highlights NTHi as a possible pathogen not only in preterm but also in term neonates. 

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