Effect of Antithyroid Peroxidase Antibody on Pregnancy Outcome in Euthyroid Women

Mirzamoradi Masoomeh, Khan Ahmadi Ahia, Marzieh Jamali, Atefeh Ebrahimi, Vafaeenia Mahya

Abstract

Background: Antithyroidperoxidase (anti-TPO) antibodies can have an adverse effect on pregnancy outcomes. The presence of these antibodies is associated with pregnancy complications such as preterm labor, macrosomia, and spontaneous miscarriage in euthyroid women. However, less is known about thyroid antibodies and their relationship with pregnancy complications.

Aim: To determine the relationship between anti-TPO antibodies and preterm labor, macrosomia, and spontaneous miscarriage in euthyroid pregnant women

Materials and Methods: This was a prospective study conducted on all the pregnant women who were referred to Mahdiyeh Hospital (Tehran, Iran) from 2014 to 2016. One hundred pregnant women with anti-TPO antibodies detected in their blood were chosen as the case group and 300 pregnant women without this antibody were chosen as the control group. The relationship between anti-TPO antibodies and preterm labor, macrosomia, and spontaneous miscarriage was studied.

Results: Of the study population, 21% with anti-TPO antibodies and 3.7% without this antibody had preterm labor. In the control group, 5.7% had spontaneous miscarriage, while 19% in the case group had spontaneous miscarriage. Regarding the occurrence of macrosomia, the difference between the case and control groups was not significant (P = .069).

Conclusion: Anti-TPO antibodies have no effect on the incidence of gestational diabetes mellitus, and therefore they do not have a significant effect on macrosomia. Despite these hypotheses, more studies analyzing the association between macrosomia and anti-TPO antibodies, with a larger statistical population, are needed.

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