Polymorphism of Hypertension Susceptibility Genes as a Risk Factor for Gestational Hypertension in Egyptian Women

Mai Mahmoud Shaker, Nesma Mohamed Elaraby, Taghreed Abdelmoniem Shalabi

Abstract

Background: Gestational hypertension (GH) is defined as blood pressure reading exceeding 140/90 mm Hg after 2 consecutive measurements taken > 6 hours apart, without proteinuria, identified after 20 weeks of gestation. Gestation-related hypertensive disorders affect 10% of pregnant women, which present a global threat to maternal and fetal well-being.

Aim: The aim of our study was to assess the correlation of different polymorphisms among different hypertension-related genes (AGTR1, AGTR2, GNB3, NOS3, ADD1, AGT, and CYP11B2) with the risk of developing GH.

Materials and Methods: This case–control study was con ducted on 511 women, of which 249 women with GH were categorized under case group and 262 normotensive pregnant women were categorized under control group. Genotyping was performed using real-time polymerase chain reaction.

Results: AGTR1 (1166 A>C), AGTR2 (1675 G>A), GNB3 (825 C>T), and NOS3 (786 T>C and 894 G>T) polymorphisms showed statis tical difference in the case group in comparison to the control group (P = .05, .67, .015, .027, and .047, respectively). Whereas ADD1 (1378 G>T), AGT (704 T>C and 521 C>T), and CYP11B2 (344 C>T) polymorphisms showed no statistical difference in the case group in comparison to the control group (P = .837, .86, .74, and .67, respectively).

Conclusion: Pregnant women with AGTR1 (1166 A>C), AGTR2 (1675 G>A), GNB3 (825 C>T), and NOS3 (786 T>C and 894 G>T) polymorphisms are at an increased risk of developing GH.