Risk Factors of Extubation Failure in Neonates Admitted to a Tertiary Care Center

Sahana Devadas, Angel Cham Philip

Abstract

Aim: To determine the risk factors associated with extubation failure (EF) in neonates

Materials and Methods: This was a prospective observational study involving neonates who were ventilated for at least 24 hours. Of the 117 enrolled neonates, 93 completed the study. The standard care was provided as per unit protocol. The demographic, ventilatory, hematologic, and biochemical parameters and complications were recorded. The primary outcome was EF within 48 hours of first elective extubation.

Results: Among the 93 neonates who completed the study, 41 experienced EF (44.08%). Statistically significant risk factors were very low birth weight (P = .012), anemia requiring packed red blood cell (PRBC) transfusion (P = .0021), culture-positive sepsis (P = .0326), and ventilation duration ≥ 5 days (P = .0002).

Conclusions: In this study, very low birth weight, anemia requiring PRBC transfusion, culture-positive sepsis, and ventilation duration ≥ 5 days were found to be the risk factors of EF.

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