Perinatal Risks and Health Outcomes in Children Born Through Assisted Reproductive Technology

Raajam Murali Subramaniam Renuka, Devika Gunasheela


One in 7 couples is infertile at some stage in their reproductive life. With an increase in in vitro fertilization (IVF) success rates, there has been a dramatic increase in the recommendations for assisted reproductive technology (ART)-related procedures. Concerns about the outcome of ART conceptions have accompanied their increased prevalence. In the United States, approximately 1.5% of all births and 20% of all multiple births are due to IVF. Although the perinatal risks associated with IVF are much higher in multiple births, even singletons are at a higher risk compared with singletons from spontaneous conceptions. In a high-order multiple pregnancy through ART, the option of fetal reduction should be offered. The perinatal health and long-term outcomes of ART pregnancies are largely reassuring. There is a need to differentiate between the effects of ART versus other confounding factors such as age and infertility on the health outcomes of children born through ART. Also, these are influenced by scientific advances in the field of ART, obstetrics, and neonatal care over time. The perinatal and health outcomes associated with children born through ART are discussed in this article.

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