Incidence of Acute Kidney Injury in Culture-Positive Sepsis

Vineet Kulkarni, Vijay Kulkarni


Aim: To evaluate the incidence of acute kidney injury (AKI) in neonatal sepsis and delineate the risk factors associated with it

Materials and Methods: This retrospective study was conducted in 100 neonates with septicemia. Detailed maternal and neonatal information about age, gender, gestational age, prenatal history, history of diseases, use of medical devices, other relevant medical conditions and laboratory results, treatment modality, and outcomes was collected. Chi-square and Fisher exact tests were used to compare categorical variables, and Student t test was used to analyze continuous variables.

Results: The study had 41.6% of LBW neonates (birth weight < 2500 g) and 43.3% of preterm neonates. About 35% of neonates with sepsis had AKI. The mean gestation period of neonates with AKI was similar to those without AKI (35.09 + 3.8 vs 35.88 + 3.76 wk, P = .56). There was no significant difference (P < .005) in the incidence of DIC and shock. AKI was successfully treated in 20 of the 35 neonates with sepsis.

Conclusion: AKI is commonly observed in septic neonates. Low birth weight (LBW) is an important risk factor, but coexisting shock and disseminated intravascular coagulation (DIC) are also significantly associated with the development of AKI.

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