Patent Ductus Arteriosus With Congenital Cytomegalovirus Infection: A Rare Presentation

Subbanna Lingaraju, Kamasani Hemachandra Reddy, Maneesha PH, Ranjan Kumar Pejaver


Congenital cytomegalovirus (CCMV) infection has a worldwide incidence of 0.2% to 2.2%, and its seroprevalence ranges between 45% and 100%. Maternal transmission to the fetus of a new or reactivated latent infection may occur at any point during the gestation, leading to CCMV infection.

Majority of infants born with CCMV infection are asymptomatic at birth. Asymptomatic CCMV infection is defined as the presence of cytomegalovirus (CMV) in any body secretions within the first 3 weeks of life, but with normal findings on clinical, laboratory, and imaging evaluations. Regardless of maternal immune status during pregnancy, 10% to 15% of neonates with CCMV have symptoms or signs at birth (eg, periventricular calcifications, intrahepatic calcifications, microcephaly, ventriculomegaly, echogenic bowel, meconium ileus, pleural effusion, and pericardial effusion). Only about 1 in 5 neonates with CCMV infection will be sick from the virus or have long-term health problems.

Here, we present an unusual case of patent ductus arteriosus (PDA) detected postnatally with CCMV infection.


  • It is not common to have congenital heart disease with CCMV infection.

  • PDA is a classic presentation of rubella infection, although it can be present in other TORCH infections.

  • When a constellation of symptoms exists, among TORCH, CMV is one of the differential diagnoses for PDA, as it is a treatable condition.

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